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Anti-Crotonyl-Histone H2B (Lys15/16/20) Rabbit mAb

Anti-Crotonyl-Histone H2B (Lys15/16/20) Rabbit mAb

Item no.	PTM-546RM
Manufacturer	PTM Biolabs
Amount	100 ul
Format	Lyophilized powder
Applications	WB, CHIP
Clone	25-H1L3
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Alias	H2BK15/K16/K20cr
Shipping condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Histone & Histone Modification Antibodies
Manufacturer - Targets	Histone H2B
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	14
Manufacturer - Research Area	Epigenetics
Product description	Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. This antibody can simultaneously identify histone H3 at Lys15, 16 and 20.
Purification Method	Protein A purified
Manufacturer - Specificity	Anti-Crotonyl-Histone H2B (Lys15/16/20) Rabbit mAb detects histone H2B when it is crotonylated at Lys15/16/20.
Constituents	PBS, Glycerol, BSA
PTM	Crotonyl
Modification Site	Lys15, Lys16, Lys20
Immunogen	Crotonylated human histone H2B (Lys15/16/20) peptide
Clonality	Recombinant Monoclonal
Stability	Stable for 12 months from date of receipt/reconstitution.
Background	Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. This antibody can simultaneously identify histone H3 at Lys15, 16 and 20.
Cellular Localization	Nucleus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 1/17/2025

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