Manufacturer |
GenScript
|
Category |
|
Type |
Proteins |
Specific against |
SARS-CoV-2 |
Amount |
100 ug |
Item no. |
Z03611-100 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Alias |
Lineage B.1.617.1; variant Kappa; VUI-21APR-01 |
Purity |
> 90% as analyzed by SDS-PAGE |
Apparent Molecular Weight |
~112 kDa, on SDS-PAGE under reducing conditions. |
Biological Activity |
This protein is validated to bind with human ACE2 in functional ELISA assay. |
Concentration |
Please refer to the COA for the specific lot. |
Endotoxin Level |
< 0.2 EU/μg of protein by gel clotting method |
Expression System |
CHO |
Formulation |
Supplied as a solution in PBS, pH 7.4. |
Protein Construction |
Expressed with the mutations of T95I, G142D, E154K, L452R, E484Q, D614G, P681R. S1 protein (Gln14-Arg685)Accession # P0DTC2 Poly-His N-term C-term |
Storage & Stability |
Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles. |
Target Background |
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. As of May 2021, three sublineages have been found. Despite its name, B.1.617.3 was the first sublineage of this variant to be detected, in October 2020 in India. This sublineage has remained relatively uncommon compared to the two other sublineages, B.1.617.1 (also known as variant Kappa) and B.1.617.2 (also known as variant Delta), both of which were first detected in December 2020. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineage B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus. |
Theoretical Molecular Weight |
75.7 kDa |
Product Origin |
USA |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.