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Human Tau-441 / 2N4R Protein, His Tag

Human Tau-441 / 2N4R Protein, His Tag

Item no.	TAU-H51H3-100ug
Manufacturer	ACROBiosystems
Amount	100 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Human
Host	E.coli
Conjugate/Tag	Unconjugated, HIS
Purity	90%
Citations	(1) Yoshida H, et al. 2012. J. Neurochem. 120:165-176. (2) Alonso A., et al. 2001.Proc. Natl. Acad. Sci. U.S.A.98 (12): 6923-8
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU
Available
Manufacturers Category	Protein / Other Recombinant Proteins
Description	Human Tau-441, His Tag (TAU-H51H3) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).
Molecule	Tau
Exp Region	Met 1 - Leu 441
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	47.9 kDa
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5
Background	Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R, " "Isoform Tau-F, " "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 8/30/2024

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