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Cynomolgus Siglec-10 Protein, His Tag (MALS verified)

Cynomolgus Siglec-10 Protein, His Tag (MALS verified)

Item no.	SI0-C52H5-100ug
Manufacturer	ACROBiosystems
Amount	100 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Monkey
Host	HEK293
Conjugate/Tag	Unconjugated, HIS
Purity	95%
Citations	(1) Whitney G., et al. 2001, Eur J Biochem., 268(23), 6083-96. (2) Kivi E., et al. 2009, Blood., 114(26), 5385-92. (3) Munday J., et al. 2001, Biochem J., 355(Pt 2), 489-97.
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	42020190
ECLASS 9.0	42020190
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
Available
Manufacturers Category	Protein / Bio-Markers & CD Antigens
Description	Cynomolgus Siglec-10, His Tag (SI0-C52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - Ala 549 (Accession # A0A2K5WBX8-1).
Molecule	Siglec-10
Exp Region	Thr 17 - Ala 549
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	60.2 kDa
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	25 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.0
Background	The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 8/9/2024

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