Item no. |
SG5-H82E9-200ug |
Manufacturer |
ACROBiosystems
|
Amount |
200 ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Conjugate/Tag |
Biotin, HIS, Avi |
Purity |
90% |
Citations |
(1) Angata T, et al. 2007. Glycobiology. 178(8):838-846. (2) Yusuke K, et al. 2015. Bone. 17:217-226. (3) Hiruma Y. et al. 2011. Biochem Biophys Res Commun. 409(3):424-9. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15 |
Available |
|
Manufacturers Category |
Protein / MABSol® Biotin Labeled Proteins |
Description |
Biotinylated Human Siglec-15 Protein, His, Avitag (SG5-H82E9) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # Q6ZMC9-1). |
Molecule |
Siglec-15 |
Exp Region |
Phe 20 - Thr 263 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
30.1 kDa |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 30.1 kDa. The protein migrates as 33-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
25 mM MES, 150 mM NaCl, pH5.5 |
Background |
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.