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SARS-CoV-2 Spike S1 Protein, His Tag (BA.2.12.1/Omicron)

SARS-CoV-2 Spike S1 Protein, His Tag (BA.2.12.1/Omicron)

Item no.	S1N-C52Hx-100ug
Manufacturer	ACROBiosystems
Amount	100 ug
Quantity options	100 ug 1 mg
Category	Peptides & Proteins Amino Acids
Type	Proteins
Format	Powder
Specific against	SARS-CoV-2
Host	HEK293
Conjugate/Tag	HIS, Unconjugated
Purity	95%
NCBI	QHD43416.1 (T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Spike,S1 protein,Spike glycoprotein Subunit1,S glycoprotein Subunit1,Spike protein S1
Shipping condition	Room temperature
Available
Manufacturer - Category	Protein / Viral Proteins
Manufacturer - Conjugate / Tag	C-10×His, Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	76.8 kDa
Description	SARS-CoV-2 Spike S1, His Tag (BA.2.12.1/Omicron) (S1N-C52Hx) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1 (T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H)). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.2.12.1; GISAID clade: GRA).
Background	It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Molecule	Spike S1
Exp Region	Val 16 - Arg 685
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.8 kDa. The protein migrates as 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, 0.2M Arginine, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

S1N-C52Hx-100ug-datasheet.pdf

S1N-C52Hx-100ug-safety-datasheet.pdf