Item no. |
RS1-H5269-50ug |
Manufacturer |
ACROBiosystems
|
Amount |
50 ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Conjugate/Tag |
Fc |
Purity |
95% |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
RSPO1,CRISTIN3,FLJ40906,RP11-566C13.1,R-spondin-1 |
Available |
|
Manufacturers Category |
Protein / Bio-Markers & CD Antigens |
Description |
Human R-Spondin 1 (21-146), Fc Tag (RS1-H5269) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Ala 146 (Accession # Q2MKA7-1). |
Molecule |
R-Spondin 1 |
Exp Region |
Ser 21 - Ala 146 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
40.2 kDa |
Characteristics |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 46-56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
52 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 |
Background |
R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.