Item no. |
PRS-XW-RP3028-0.1mg |
Manufacturer |
ProSci
|
Amount |
0.1 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid |
Applications |
WB, ELISA, MS |
Specific against |
other |
Dry ice |
Yes
|
ECLASS 5.1 |
34160400 |
ECLASS 6.1 |
34160400 |
ECLASS 8.0 |
42020190 |
ECLASS 9.0 |
42020190 |
ECLASS 10.0.1 |
32160409 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
RO, CRT, SSA, cC1qR, HEL-S-99n, CRTC, Calreticulin, CRP55, ERp60 |
Available |
|
Applications |
This recombinant protein can be used for WB, ELISA, MS. |
Applications |
This recombinant protein can be used for WB, ELISA, MS. |
Buffer |
10 mM Tris, pH 8.0, 0.002% NaN3, 3mM NaCl, 2.5mM |
Storage Conditions |
Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
Disclaimer |
For research use only. |
Predicted Molecular Weight |
46 kDa (Calculated) |
Purity |
~90% |
Background |
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. |
1St Image Caption3 |
SDS PAGE: Analysis of CALR Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. |
Background References 1 |
Horibe, T., Matsui, H., Tanaka, M., Nagai, H., Yamaguchi, Y., Kato, K. and Kikuchi, M. Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochem. Biophys. Res. Commun. 323 (1), 281-287 (2004) |
Accession # |
NP_004334 |
Ncbi Gene Id # |
811 |
Ncbi Official Symbol |
CALR |
Ncbi Official Full Name |
calreticulin |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P27797 |
Sequence |
aa. 18-417 |
Biological Activity |
N/A |
Protein Gi# |
4757900 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.