Item no. |
PRS-96-739-0.1mg |
Manufacturer |
ProSci
|
Amount |
0.1 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized |
Applications |
WB |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
TNFRSF11B, OCIF, OPG, Osteoprotegerin |
Available |
|
Applications |
This recombinant protein can be used for WB. For research use only. |
Applications |
This recombinant protein can be used for WB. For research use only. |
Buffer |
PBS, pH7.4 |
Storage Conditions |
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Predicted Molecular Weight |
44.4 kDa |
Purity |
>95% as determined by SDS-PAGE. |
Background |
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. |
1St Image Caption3 |
Human Osteoprotegerin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Background References 1 |
Tsuda E., et al, 1997, Biochem. Biophys. Res. Commun. 234:137-142. |
Background References 2 |
Emery J.G., et al., 1998, J. Biol. Chem. 273:14363-14367. |
Background References 3 |
Luan X., et al., 2012, J. Immunol. 189:245-252. |
Accession # |
NP_002537 |
Ncbi Gene Id # |
4982 |
Ncbi Official Symbol |
TNFRSF11B |
Ncbi Official Full Name |
tumor necrosis factor receptor superfamily, member 11b |
Ncbi Organism |
Homo sapiens |
Swissprot # |
O00300 |
Fusion Tag |
His Tag |
Sequence |
Glu 22 - Leu 401 |
Biological Activity |
Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10μ g/ml (100μ l/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/mL. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.