Item no. |
PRS-96-245-0.05mg |
Manufacturer |
ProSci
|
Amount |
0.05 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized |
Applications |
WB |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
DPP4, ADABP, ADCP2, CD26, DPPIV, TP103 |
Available |
|
Applications |
This recombinant protein can be used for WB. For research use only. |
Applications |
This recombinant protein can be used for WB. For research use only. |
Buffer |
PBS, pH7.4 |
Storage Conditions |
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Predicted Molecular Weight |
85.4 kDa |
Purity |
>95% as determined by SDS-PAGE. |
Background |
Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established. |
1St Image Caption3 |
The purity of rh DPPIV was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue. |
Background References 1 |
Kameoka J, et al., 1993, Science, 261 (5120): 466-9. |
Background References 2 |
Chen X, 2006, Adv. Exp. Med. Biol. 575: 27–32. |
Background References 3 |
Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4. |
Background References 4 |
Havre PA, et al., 2008, Front. Biosci. 13: 1634–45. |
Accession # |
NP_001926.2 |
Ncbi Gene Id # |
1803 |
Ncbi Official Symbol |
DPP4 |
Ncbi Official Full Name |
dipeptidyl-peptidase 4 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P27487 |
Fusion Tag |
His Tag |
Sequence |
Asn 29 - Pro 766 |
Biological Activity |
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GPAMC). The specific activity is >3000 pmol/min/μ g. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.