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FNDC5:Fc Recombinant Protein

FNDC5:Fc Recombinant Protein

Item no.	PRS-90-334-10ug
Manufacturer	ProSci
Amount	10 ug
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Neural Adhesion Molecules Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Obesity Cell Stainings ECM
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2.
Available
Applications	This recombinant proteins is for research use only.
Applications	This recombinant proteins is for research use only.
Buffer	Contains PBS. Reconstitute with 100 μ l sterile water.
Storage Conditions	Stable for at least 6 months after receipt when stored at -20˚ C.
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Purity	>95% (SDS-PAGE). Endotoxin level is less than 0.01EU/ μ g purified protein (LAL test; Lonza).
Background	Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. The membrane receptor FNDC5 can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).
Concentration	0.1mg/ml after reconstitution.
Accession #	Q8NAU1
Ncbi Gene Id #	252995
Ncbi Official Symbol	FNDC5
Ncbi Official Full Name	fibronectin type III domain containing 5
Ncbi Organism	Homo sapiens
Swissprot #	P13500
Fusion Tag	Fc Tag
Sequence	FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human.
Biological Activity	N/A
Protein Gi#	403314395

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 9/6/2024

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