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GDNF Recombinant Protein

GDNF Recombinant Protein

Manufacturer	ProSci
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Format	Lyophilized
Amount	0.01 mg
Item no.	PRS-40-499-0.01mg
eClass 6.1	34160400
eClass 9.0	42020190
Available
Alias	ATF1, ATF2, HSCR3, HFB1-GDNF, Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor, hGDNF
Storage Conditions	The lyophilized GDNF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted GDNF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing GDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Disclaimer	This product is for research use only.
Purity	Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μ g (1EU/μ g).
Background	GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Accession #	NP_000505.1
Ncbi Gene Id #	2668
Ncbi Official Symbol	GDNF
Ncbi Official Full Name	glial cell derived neurotrophic factor
Ncbi Organism	Homo sapiens
Swissprot #	P39905
Sequence	MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Biological Activity	Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
Protein Gi#	4503975
Peptide Sequence	MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.01 mg

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Delivery expected until 8/2/2024

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