Item no. |
PRS-40-387-0.005mg |
Manufacturer |
ProSci
|
Amount |
0.005 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
MDC, ABCD-1, SCYA22, STCP-1, DC/B-CK, A-152E5.1, MDC, C-C motif chemokine 22, CC chemokine STCP-1 |
Available |
|
Storage Conditions |
The lyophilized MDC recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MDC is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MDC recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
Disclaimer |
This product is for research use only. |
Purity |
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μ g (1EU/μ g). |
Background |
MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. |
Accession # |
NP_002981.2 |
Ncbi Gene Id # |
6367 |
Ncbi Official Symbol |
CCL22 |
Ncbi Official Full Name |
chemokine (C-C motif) ligand 22 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
O00626 |
Sequence |
YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ |
Biological Activity |
Biological activity was determined by its ability to chemoattract human T cells using a concentration range of 10.0 - 100.0 ng/mL. |
Protein Gi# |
22538804 |
Peptide Sequence |
YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.