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Activin A Recombinant Protein

Activin A Recombinant Protein

Item no.	PRS-40-212-0.01mg
Manufacturer	ProSci
Amount	0.01 mg
Category	Oncology Peptides & Proteins Recombinant Proteins By Organ Breast Cancer
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2
Available
Storage Conditions	The lyophilized Activin A recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Activin A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Disclaimer	This product is for research use only.
Purity	Greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per μ g (1EU/μ g).
Background	Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, Follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two β A chains, each containing 116 amino acid residues.
Accession #	NP_001003652.1
Ncbi Gene Id #	4087
Ncbi Official Symbol	SMAD2
Ncbi Official Full Name	SMAD family member 2
Ncbi Organism	Homo sapiens
Swissprot #	Q15796
Sequence	GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Biological Activity	The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ≤ 2 ng/mL, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.
Protein Gi#	51173730
Peptide Sequence	GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 9/6/2024

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