Activin RIB / ACVR1B Recombinant Protein

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.3 kDa. The protein migrates as 16-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

13.3 kDa

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Carcamo J., et al., 1994, Mol. Cell. Biol. 14:3810-3821.

Harrison C.A., et al., 2003, J. Biol. Chem. 278:21129-21135.

91

activinAreceptortype1B

P36896

Ser 24 - Glu 126