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Human NOTCH3 Protein, Fc Tag

Human NOTCH3 Protein, Fc Tag

Item no.	NO3-H5255-1mg
Manufacturer	ACROBiosystems
Amount	1 mg
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Human
Host	HEK293
Conjugate/Tag	Unconjugated, Fc
Purity	95%
Citations	(1) Kopan R., Ilagan M.X. Cell. 2009;137:216-233. (2) Bray S.J. Nat. Rev. Mol. Cell Biol. 2016;17:722-735. (3) Baron M. Mol. Membr. Biol. 2017;34:33-49. (4) Peters N, Exp Cell Res. 2004 Oct 1;299(2):454-64. (5) Hosseini-Alghaderi S, Baron M. Biomolecules. 2020 Mar 23;10(3):485.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Notch-3,NOTCH3
Available
Manufacturers Category	Protein / Other Recombinant Proteins
Description	Human NOTCH3, Fc Tag (NO3-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 40 - Glu 467 (Accession # Q9UM47-1).
Molecule	NOTCH3
Exp Region	Ala 40 - Glu 467
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	71.4 kDa
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 71.4 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Background	Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

available

Delivery expected until 9/20/2024