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Recombinant human alpha-Synuclein (A30P/A53T) protein

Recombinant human alpha-Synuclein (A30P/A53T) protein

Item no.	NKM-SNA2004-20ug
Manufacturer	NKMAX
Amount	20ug
Category	Oncology Neuroscience Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Infectious Diseases Viral Infections Coronavirus (COVID-19) By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Adenocarcinoma Autophagy SDS-PAGE
Type	Proteins Recombinant
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	Non-Tagged
Purity	> 95% by SDS-PAGE
Citations	Kim KS, et al. Proteolytic cleavage of extracellular a-synuclein by plasmin: implications for Parkinson disease. J Biol Chem. 2012 Jul 20;287(30):24862-72.{https://pubmed.ncbi.nlm.nih.gov/22619171/}
NCBI	NP_000336.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SNCA, NACP, PARK1, alpha-Synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Alpha synuclein, Alpha-synuclein isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of PARK 1, PARK 4, PARK4, Parkinson disease familial 1, PD 1, PD1, Synuclein alpha,
Available
Antigen Species	Human
Bioassay Procedure	MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Concentration	1mg/ml (determined by BCA assay)
Description	A Parkinson's disease-related double mutant (A30P/A53T) of alpha-synuclein. The recombinant protein was purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques
Domain	1-140aa
Expression System	E.coli
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl
Gene Category	Neuroscience
General References	Kruger R., et al. (1998) Nat Genet. 18, 106-108.; ; Polymeropoulos MH., et al. (1997) Science. 276, 2045-7.; ; Park, SM. et al. (2002) Blood. 100(7), 2506-2514
Molecular Weight	14.5 kDa (140aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 8/30/2024

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