Recombinant human ST6 GalNAc α-2.6- sialyltransferase V/ST6GALNAC5 protein

GGQKERP PQQQQQQQQQ QQQASATGSS QPAAESSTQQ RPGVPAGPRP LDGYLGVADH KPLKMHCRDC ALVTSSGHLL HSRQGSQIDQ TECVIRMNDA PTRGYGRDVG NRTSLRVIAH SSIQRILRNR HDLLNVSQGT VFIFWGPSSY MRRDGKGQVY NNLHLLSQVL PRLKAFMITR HKMLQFDELF KQETGKDRKI SNTWLSTGWF TMTIALELCD RINVYGMVPP DFCRDPNHPS VPYHYYEPFG PDECTMYLSH ERGRKGSHHR FITEKRVFKN WARTFNIHFF QPDWKPESLA INHPENKPVF

ST6GALNAC5, also known as Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 5, is a member of the glycosyltransferase 29 family. This protein is a sialyltransferase involved in the biosynthesis of ganglioside GD1a from GM1b. It is involved in the pathway protein glycosylation, which is part of Protein modification. It's expression is restricted to the brain normally. It has been identified as a key player in the metastasis of breast cancer cells to the brain by potentially enabling the cancer cells to cross the blood-brain barrier. Recombinant human ST6GALNAC5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

< 1 EU per 1ug of protein (determined by LAL method)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Kolter, T. et al. (2002) J. Biol. Chem. 277:25859-25862.; ; Okajima, T. et al. (1999) J. Biol. Chem.274:30557-30562.; ; Harduin-Lepers, A. et al. (2005) Glycobiology 15:805-817.; ;

Ala39