Item no. |
NKM-ATGP3861-10ug |
Manufacturer |
NKMAX
|
Amount |
10ug |
Category |
|
Type |
Proteins Recombinant |
Applications |
SDS-PAGE |
Specific against |
other |
Conjugate/Tag |
Non-Tagged |
Purity |
> 95% by SDS-PAGE |
NCBI |
NP_068575 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Interleukin-21 isoform 1, CVID11, IL-21, Za11 |
Available |
|
Antigen Species |
Human |
Bioactivity Comment Only |
The activity is determined by the IFN-g ELISA in a using NK-92 human natural killer cells. The ED50 range <=4ng/ml. |
Bioactivity Comment and Pics |
Human IL-21 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range <=4 ng/ml. |
Bioassay Procedure |
MQGQDRHMIR MRQLIDIVDQ LKNYVNDLVP EFLPAPEDVE TNCEWSAFSC FQKAQLKSAN TGNNERIINV SIKKLKRKPP STNAGRRQKH RLTCPSCDSY EKKPPKEFLE RFKSLLQKMI HQHLSSRTHG SEDS |
Concentration |
0.25mg/ml (determined by absorbance at 280nm) |
Description |
IL-21, also known as Interleukin-21, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cell, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival Time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells. Recombinant human IL-21, was expressed in E. coli and purified by using conventional chromatography techniques. |
Domain |
30-162 aa |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Expression System |
E.coli |
Formulation |
Liquid in. Phosphate-Buffered Saline (pH 7.4) |
Gene Category |
Growth factors |
General References |
Gui G., et al. (2017) Clin Immunol. 183:266-272.; ; Parrish-Novak J., et al. (2000) Nature. 408(6808):57-63. |
Molecular Weight |
15.5 kDa (134aa) confirmed by MALDI-TOF |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.