Recombinant human PVR protein

SDS-PAGE

PVR, also known as poliovirus receptor isoform alpha, is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. It catalyzes a large structural change in the virus that exposes membrane-binding protein chains. It plays an important regulatory role in helper T cell differentiation and allergic diseases. It is expressed in many types of human cells and has diverse functions. It may be potentially useful as a biomarker for cancer development and progression. It may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer. Recombinant human PVR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

< 1.0 EU per 1ug of protein (determined by LAL method)

Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.

Nishiwada S., et al. (2015) Anticancer Res. 35:2287-2297.
Strauss M., et al. (2015) J Virol. 89:4143-4157.

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.