Item no. |
NKM-ATGP3612-50ug |
Manufacturer |
NKMAX
|
Amount |
50ug |
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Conjugate/Tag |
hIgG-His-Tag |
Purity |
> 90% by SDS - PAGE |
Sequence |
ADPPGWFLDS PDRPWNPPTF SPALLVVTEG DNATFTCSFS NTSESFVLNW YRMSPSNQTD KLAAFPEDRS QPGQDCRFRV TQLPNGRDFH MSVVRARRND SGTYLCGAIS LAPKAQIKES LRAELRVTER RAEVPTAHPS PSPRPAGQFQ TLVLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP R |
NCBI |
NP_005009 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Programmed cell death protein 1, PDCD1, CD279, hPD-1, hPD-l, hSLE1, PD-1, PD1, SLEB2 |
Available |
|
Antigen Species |
Human |
Applications info |
SDS-PAGE |
Concentration |
0.5mg/ml (determined by Absorbance at 280nm) |
Description |
PDCD1, also known as programmed cell death protein 1, is a type 1 transmembrane glycoprotein, and is an immune-receptor belonging to the CD28/CTLA4 family. This protein is expressed on the surface of activated T-cell, B-cell, macrophages, myeloid cells and subset of thymocytes. Also, it inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4 and IL-10. As a cell surface molecule, it regulates the adaptive immune response. Recombinant human PDCD1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
Domain |
21-170aa |
Endotoxin |
< 1.0 EU per 1ug of protein (determined by LAL method) |
Expression System |
Baculovirus |
Formulation |
Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Gene Category |
Apoptosis |
General References |
Ishida Y., et al, (1992) EMBO J. 11:3887-3895. Lastwika KJ., et al, (2016) Cancer Res. 76:227-238. |
Molecular Weight |
44.0kDa (392aa) 40-57kDa (SDS-PAGE under reducing conditions.) |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.