Recombinant human PD-1 protein

SDS-PAGE

PDCD1, also known as programmed cell death protein 1, is a type 1 transmembrane glycoprotein, and is an immune-receptor belonging to the CD28/CTLA4 family. This protein is expressed on the surface of activated T-cell, B-cell, macrophages, myeloid cells and subset of thymocytes. Also, it inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4 and IL-10. As a cell surface molecule, it regulates the adaptive immune response. Recombinant human PDCD1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

< 1.0 EU per 1ug of protein (determined by LAL method)

Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.

Ishida Y., et al, (1992) EMBO J. 11:3887-3895.
Lastwika KJ., et al, (2016) Cancer Res. 76:227-238.

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.