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Recombinant mouse CXCL12/SDF-1 protein

Recombinant mouse CXCL12/SDF-1 protein

Item no.	NKM-ATGP3159-50ug
Manufacturer	NKMAX
Amount	50ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	His-Tag
Purity	> 95% by SDS-PAGE
NCBI	NP_068350.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Stromal cell-derived factor 1 isoform alpha, Pbsf, Scyb12, Sdf1, Tlsf, Tpar1
Available
Antigen Species	Mouse
Bioassay Procedure	KPVSLSY RCPCRFFESH IARANVKHLK ILNTPNCALQ IVARLKNNNR QVCIDPKLKW IQEYLEKALN K
Concentration	0.25mg/ml (determined by absorbance at 280nm)
Description	Cxcl12 also known as stromal cell-derived factor 1 isoform alpha. This protein acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. This protein inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Cxcl12 protein plays a protective role after myocardial infarction. It induces down-regulation and internalization of ACKR3 expressed in various cells. Recombinant mouse Cxcl12, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques
Domain	22-89aa
Expression System	E.coli
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Category	Hormones & Cytokines
General References	Beaulande M., et al. (1998) Nucleic Acids. 26(2):521-4; ; Chen T., et al. (2015) Am J Transplant. 15(3):618-27
Molecular Weight	10.4 kDa (91aa) confirmed by MALDI-TOF
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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