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Recombinant human PDE6H protein

Recombinant human PDE6H protein

Item no.	NKM-ATGP2785-10ug
Manufacturer	NKMAX
Amount	10ug
Category	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Cell Biology Cytoskeleton SDS-PAGE Cardiovascular Research Thrombosis & Hemostasis small GTPases Rho Subfamily
Type	Proteins Recombinant
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	His-Tag
Purity	> 80% by SDS-PAGE
NCBI	NP_006196
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Retinal cone rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ACHM6, RCD3
Available
Antigen Species	Human
Bioassay Procedure	MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFG DDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII
Concentration	0.5mg/ml (determined by Bradford assay)
Description	PDE6H is the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). Recombinant human PDE6H protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Domain	1-83aa
Expression System	E.coli
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 2mM DTT, 0.1mM PMSF
Gene Category	Signal Transduction
General References	Shimizu-Matsumoto A., et al. (1996) Genomics 32:121-124.
Molecular Weight	11.5 kDa (106aa) confirmed by MALDI-TOF

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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