Item no. |
NKM-ATGP1953-0.5mg |
Manufacturer |
NKMAX
|
Amount |
0.5mg |
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Conjugate/Tag |
His-Tag |
Purity |
> 85% by SDS - PAGE |
Sequence |
MGSSHHHHHH SSGLVPRGSH MGSLQQEDGI SFEYHRYPEL REALVSVWLQ CTAISRIYTV GRSFEGRELL VIELSDNPGV HEPGEPEFKY IGNMHGNEAV GRELLIFLAQ YLCNEYQKGN ETIVNLIHST RIHIMPSLNP DGFEKAASQP GELKDWFVGR SNAQGIDLNR NFPDLDRIVY VNEKEGGPNN HLLKNMKKIV DQNTKLAPET KAVIHWIMDI PFVLSANLHG GD |
NCBI |
NP_001864 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Carboxypeptidase E, Carboxypeptidase H, CPH |
Available |
|
Antigen Species |
Human |
Applications info |
SDS-PAGE |
Concentration |
0.5 mg/ml (determined by Bradford assay) |
Description |
CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but constitutively secreted proteins. Mutations in CPE are implicated in type II diabetes. Recombinant human CPE protein, fused to His-tag at N-terminus, was expressed in E. coli. |
Domain |
43-476aa |
Expression System |
E.coli |
Formulation |
Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
Gene Category |
Metabolism |
General References |
Chu, K.Y., et al. (2011) Islets 3 (4), 155-165 Lee, T.K., et al. (2011) J. Clin. Invest. 121 (3), 880-892 |
Molecular Weight |
51.4 kDa (457aa) |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.