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Recombinant human MMACHC protein

Recombinant human MMACHC protein

Item no.	NKM-ATGP1574-500ug
Manufacturer	NKMAX
Amount	500ug
Category	Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	His-Tag
Purity	> 90% by SDS-PAGE
NCBI	NP_056321
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MMACHC, Methylmalonic aciduria and homocystinuria type C protein, RP11-291L19.3, cblC
Available
Antigen Species	Human
Concentration	0.5mg/ml (determined by Bradford assay)
Description	The exact function of MMACHC is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this protein are associated with methylmalonic aciduria and homocystinuria type cblC. Recombinant human MMACHC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Expression System	E.coli
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Gene Category	Signal Transduction
General References	Lerner-Ellis JP., et al. (2006) Nat Genet. 38(1):93-100.; ; Tsai AC., et al. (2007) Am. J. Med. Genet. A 143A (20): 2430-4.
Molecular Weight	34 kDa (306aa) confirmed by MALDI-TOF
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500ug

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Delivery expected until 10/4/2024

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