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Recombinant human CBX3 protein

Recombinant human CBX3 protein

Item no.	NKM-ATGP1456-20ug
Manufacturer	NKMAX
Amount	20ug
Category	Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	His-Tag
Purity	> 90% by SDS-PAGE
NCBI	NP_057671
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Chromobox protein homolog 3, HECH, HP1-GAMMA, HP1Hs-gamma
Available
Antigen Species	Human
Bioassay Procedure	MASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ
Concentration	1mg/ml (determined by Bradford assay)
Description	CBX3, also known as chromobox protein homolog 3, seems to be involved in transcriptional silencing in heterochromatin-like complexes. This protein recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. It involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Recombinant human CBX3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Domain	1-183aa
Expression System	E.coli
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Gene Category	Epigenomics (Transcription & Translation)
General References	Koike N., et al. (2000) FEBS Lett. 467:17-21; ; Lachner M., et al. (2001) Nature. 410:116-120; ;
Molecular Weight	23.4 kDa (207aa) confirmed by MALDI-TOF

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 8/30/2024

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