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Recombinant human SOD2/Mn-SOD protein

Recombinant human SOD2/Mn-SOD protein

Item no.	NKM-ATGP0512-20ug
Manufacturer	NKMAX
Amount	20ug
Category	Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins Cell Biology Cell Metabolism SDS-PAGE
Type	Proteins Recombinant
Applications	SDS-PAGE
Specific against	other
Conjugate/Tag	His-Tag
Purity	> 95% by SDS-PAGE
Citations	Kwon MJ, et al. Superoxide dismutase 3 controls adaptive immune responses and contributes to the inhibition of ovalbumin-induced allergic airway inflammation in mice. Antioxid Redox Signal. 2012 Nov 15;17(10):1376-92. {https://pubmed.ncbi.nlm.nih.gov/22583151/}
NCBI	NP_001019636.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Superoxide dismutase [Mn] mitochondrial, IPOB, MNSOD, MVCD6, Superoxide dismutase [Mn], mitochondrial IPO B, Manganese SOD, Manganese superoxide dismutase, Mn SOD, SOD 2, SOD2, Superoxide dismutase [Mn] mitochondrial, Superoxide dismutase 2 mitochondrial, Superoxide Dismutase-2
Available
Antigen Species	Human
Bioactivity Comment Only	Specific activity is > 1, 000unit/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.5 at 25C.
Bioactivity Comment and Pics	Specific activity is > 1, 000 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.5 at 25C.
Bioassay Procedure	KHSLPDLPY DYGALEPHIN AQIMQLHHSK HHAAYVNNLN VTEEKYQEAL AKGDVTAQIA LQPALKFNGG GHINHSIFWT NLSPNGGGEP KGELLEAIKR DFGSFDKFKE KLTAASVGVQ GSGWGWLGFN KERGHLQIAA CPNQDPLQGT TGLIPLLGID VWEHAYYLQY KNVRPDYLKA IWNVINWENV TERYMACKK
Concentration	0.5mg/ml (determined by Bradford assay)
Description	SOD2 is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this protein have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Recombinant human SOD2 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Domain	25-222aa
Expression System	E.coli
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Gene Category	Redox Proteins
General References	MacMillan-Crow L.A., et al. (1999) Arch. Biochem. Biophys. 366:82-88; ; Prunotto M, et al. (2010) J Am Soc Nephrol. 21(3):507-19.; ;
Molecular Weight	24.4 kDa (219aa) confirmed by MALDI-TOF

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20ug

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Delivery expected until 10/4/2024

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