Item no. |
NKM-ATGP0512-20ug |
Manufacturer |
NKMAX
|
Amount |
20ug |
Category |
|
Type |
Proteins Recombinant |
Applications |
SDS-PAGE |
Specific against |
other |
Conjugate/Tag |
His-Tag |
Purity |
> 95% by SDS-PAGE |
Citations |
Kwon MJ, et al. Superoxide dismutase 3 controls adaptive immune responses and contributes to the inhibition of ovalbumin-induced allergic airway inflammation in mice. Antioxid Redox Signal. 2012 Nov 15;17(10):1376-92. {https://pubmed.ncbi.nlm.nih.gov/22583151/} |
NCBI |
NP_001019636.1 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Superoxide dismutase [Mn] mitochondrial, IPOB, MNSOD, MVCD6, Superoxide dismutase [Mn], mitochondrial IPO B, Manganese SOD, Manganese superoxide dismutase, Mn SOD, SOD 2, SOD2, Superoxide dismutase [Mn] mitochondrial, Superoxide dismutase 2 mitochondrial, Superoxide Dismutase-2 |
Available |
|
Antigen Species |
Human |
Bioactivity Comment Only |
Specific activity is > 1, 000unit/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.5 at 25C. |
Bioactivity Comment and Pics |
Specific activity is > 1, 000 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.5 at 25C. |
Bioassay Procedure |
KHSLPDLPY DYGALEPHIN AQIMQLHHSK HHAAYVNNLN VTEEKYQEAL AKGDVTAQIA LQPALKFNGG GHINHSIFWT NLSPNGGGEP KGELLEAIKR DFGSFDKFKE KLTAASVGVQ GSGWGWLGFN KERGHLQIAA CPNQDPLQGT TGLIPLLGID VWEHAYYLQY KNVRPDYLKA IWNVINWENV TERYMACKK |
Concentration |
0.5mg/ml (determined by Bradford assay) |
Description |
SOD2 is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this protein have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Recombinant human SOD2 protein was expressed in E. coli and purified by using conventional chromatography techniques. |
Domain |
25-222aa |
Expression System |
E.coli |
Formulation |
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol |
Gene Category |
Redox Proteins |
General References |
MacMillan-Crow L.A., et al. (1999) Arch. Biochem. Biophys. 366:82-88; ; Prunotto M, et al. (2010) J Am Soc Nephrol. 21(3):507-19.; ; |
Molecular Weight |
24.4 kDa (219aa) confirmed by MALDI-TOF |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.