Item no. |
NKM-ATGP0391-500ug |
Manufacturer |
NKMAX
|
Amount |
500ug |
Category |
|
Type |
Proteins Recombinant |
Applications |
SDS-PAGE |
Specific against |
other |
Conjugate/Tag |
Non-Tagged |
Purity |
> 90% by SDS-PAGE |
NCBI |
NP_001092195 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
TCL1A, T-cell leukemia/lymphoma 1A, TCL1, TCL-1, protein p14TCL1, Oncogene TCL1, T-cell leukemia/lymphoma 1A anti TCL1A, P14 TCL1, P14 TCL1 protein, T cell leukemia 1, T cell lymphoma 1, T cell lymphoma 1A, TCL 1 protein, TCL1 oncogene, TCL1 PEN, TCL1A, TCL1A. |
Available |
|
Antigen Species |
Human |
Concentration |
1mg/ml (determined by Bradford assay) |
Description |
TCL1A, also known as T-cell leukemia/lymphoma 1A, is a protein with a suggested role in intracellular regulation of T cell signaling. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1A may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism. Recombinant TCL1A protein was expressed in E. coli and purified by using conventional chromatography techniques |
Expression System |
E.coli |
Formulation |
Liquid in. 50mM Tris-HCl buffer (pH 7.5) containing 10% glycerol |
Gene Category |
Signal Transduction |
General References |
Herling M., et al. (2006) Leukemia. 20(2):280-5.; ; Hoyer KK., et al. (2005) J Immunol. 175(2):864-73.; ; |
Molecular Weight |
13.4 kDa (114aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher) |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.