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Human Mesothelin / MSLN (37-286) Protein, His Tag

Human Mesothelin / MSLN (37-286) Protein, His Tag

Item no.	MSN-H5222-1mg
Manufacturer	ACROBiosystems
Amount	500 ug x 2
Quantity options	100 ug 500 ug x 2
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	Unconjugated, HIS
Purity	95%
Citations	(1) Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140. (2) Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808. (3) Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198. (4) Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
NCBI	AAH09272
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MSLN,Mesothelin,MPF
Shipping condition	Room temperature
Available
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	Unconjugated, C-6xHis
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	27.5 kDa
Description	Human Mesothelin (37-286), His Tag (MSN-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 37 - Arg 286 (Accession # AAH09272).
Background	Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Molecule	Mesothelin
Exp Region	Leu 37 - Arg 286
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.5 kDa. The protein migrates as 32 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution.For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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MSN-H5222-1mg-datasheet.pdf

MSN-H5222-1mg-safety-datasheet.pdf