Item no. |
LA1-H5252-1mg |
Manufacturer |
ACROBiosystems
|
Amount |
1 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Conjugate/Tag |
Unconjugated, Fc |
Purity |
95% |
Citations |
(1) Pioli C, et all., 2000, J Immunol. 15;165(10):5530-6. (2) Brondijk TH, et all., 2010, Blood. 18;115(7):1364-73 (3) Meyaard L, et all., 1997, Immunity. Aug;7(2):283-90. |
ECLASS 5.1 |
34160400 |
ECLASS 6.1 |
34160400 |
ECLASS 8.0 |
42020190 |
ECLASS 9.0 |
42020190 |
ECLASS 10.0.1 |
32160409 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
LAIR1,CD305 |
Available |
|
Manufacturers Category |
Protein / Immune Checkpoint Proteins |
Description |
Human LAIR-1, Fc Tag (LA1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - His 163 (Accession # Q6GTX8-1). |
Molecule |
LAIR-1 |
Exp Region |
Gln 22 - His 163 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
42.1 kDa |
Characteristics |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
Tris with Glycine, Arginine and NaCl, pH7.5 |
Background |
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.