Item no. |
KMD-MOP2074-50ug |
Manufacturer |
KMD Bioscience
|
Amount |
50 ug |
Category |
|
Type |
Proteins Recombinant |
Specific against |
Mouse |
Host |
Mammalian cell |
Conjugate/Tag |
His |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2, CD86 antigen |
Available |
|
Molecular Name |
Cd86 |
Source |
This protein contains the mouse Cd86(Val24-Lys244) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
Uniprot Accession |
P42082 |
Purity |
>=90% as determined by SDS-PAGE |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method. |
Buffer |
PBS |
Purification |
Protein A/G |
Predicted Molecular Weight |
24.31kDa |
Background |
B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 2 - 1 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. |
Storage |
Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles. |
Shipping Condition |
This product is shipped on ice packs or dry ice. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.