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Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free

Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free

Item no.	IT1-H52W8-1mg
Manufacturer	ACROBiosystems
Amount	200 ug x 5
Quantity options	100 ug 200 ug x 5
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	Unconjugated, HIS
Purity	90%
Citations	(1) Hodges, BL., et al., 1997, Journal of Cell Science, 110 (22): 2873-2881. (2) Mielenz, D., et al., 2001, The Journal of Biological Chemistry, 276 (16): 13417-13426. (3) Samson T., et al., 2004, J. Biol. Chem. 279 (27): 28641-28652.
NCBI	NP_002197.2 (ITGA7X2B) , NP_002202.2 (ITGB1)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Integrin isoform alpha-7X2B beta 1,ITGA7X2BB1,ITGA7X2B&ITGB1
Shipping condition	Room temperature
Available
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	Unconjugated, C-10xHis \| Native
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	116.5 kDa (ITGA7X2B) & 83.7 kDa (ITGB1)
Description	Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W8) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1)).
Background	Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
Molecule	Integrin isoform alpha-7X2B beta 1
Exp Region	Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1)
Characteristics	Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-135 kDa (ITGA7X2B) and 100-125 kDa (ITGB1) respectively due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution.For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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IT1-H52W8-1mg-datasheet.pdf

IT1-H52W8-1mg-safety-datasheet.pdf