Item no. |
IT1-H52W7-1mg |
Manufacturer |
ACROBiosystems
|
Amount |
100 ug x 10 |
Quantity options |
100 ug
100 ug x 10
|
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human (Homo sapiens) |
Host |
HEK293 |
Conjugate/Tag |
Unconjugated, HIS |
Purity |
90% |
Citations |
(1) Tachibana I, et al., 1997, The Journal of Biological Chemistry, 272 (46): 29181-29189. (2) Tani TT, et al., 2001, The Journal of Biological Chemistry, 276 (39): 36535-36542. (3) Lipscomb EA, etal., 2005, Cancer Metastasis Reviews, 24 (3): 413-423. |
NCBI |
NP_000201.2 (ITGA6) , NP_002202.2 (ITGB1) |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Integrin alpha 6 beta 1,ITGA6&ITGB1 |
Shipping condition |
Room temperature |
Available |
|
Manufacturer - Category |
Protein / Bio-Markers & CD Antigens |
Manufacturer - Conjugate / Tag |
Unconjugated, C-10xHis | Native |
Shipping Temperature |
RT |
Storage Conditions |
-20°C |
Molecular Weight |
116.8 kDa (ITGA6) & 83.7 kDa (ITGB1) |
Description |
Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W7) is expressed from human 293 cells (HEK293). It contains AA Phe 24 - Gly 1012 (ITGA6) & Gln 21 - Asp 728 (ITGB1) (Accession # P23229-2 (ITGA6) & P05556-1 (ITGB1)). |
Background |
Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1. |
Molecule |
Integrin alpha 6 beta 1 |
Exp Region |
Phe 24 - Gly 1012 (ITGA6) & Gln 21 - Asp 728 (ITGB1) |
Characteristics |
Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA6 and ITGB1, has a calculated MW of 116.8 kDa (ITGA6) and 83.7 kDa (ITGB1). Subunit ITGA6 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 140-150 kDa (ITGA6) and 100-118 kDa (ITGB1) respectively due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
50 mM Tris, 150 mM NaCl, pH7.5 |
Stability |
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution.For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Protectant |
trehalose |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.