Item no. |
ILR-M52H1-100ug |
Manufacturer |
ACROBiosystems
|
Amount |
100 ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Mouse |
Host |
HEK293 |
Conjugate/Tag |
Unconjugated, HIS |
Purity |
95% |
Citations |
(1) Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54-9. (2) Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11): 6382-7. (3) Hage T., et al., 1999, Cell 97 (2): 271-81. (4) Gessner,A. et al., 2000, Immunobiology. 201 (3-4): 285-307. (5) WillsKarp, M., F.D. Finkelman, 2008, Sci. Signal. 1:pe55. |
ECLASS 5.1 |
34160400 |
ECLASS 6.1 |
34160400 |
ECLASS 8.0 |
42020190 |
ECLASS 9.0 |
42020190 |
ECLASS 10.0.1 |
32160409 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
IL4R,CD124,IL4RA |
Available |
|
Manufacturers Category |
Protein / Bio-Markers & CD Antigens |
Description |
Mouse IL-4 R alpha, His Tag (ILR-M52H1) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Arg 233 (Accession # NP_001008700). |
Molecule |
IL-4 R alpha |
Exp Region |
Ile 26 - Arg 233 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
26.3 kDa |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 37-45 kDa under reducing (R) condition (SDS-PAGE). |
Endotoxin |
1.0 EU per μg |
Buffer |
PBS, pH7.4 |
Background |
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13. Interleukin-4 receptor has been shown to interact with SHC1. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.