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RANKL/TNFSF11, Cynomolgus (HEK293, Fc)

RANKL/TNFSF11, Cynomolgus (HEK293, Fc)

Item no.	HY-P75999-20ug
Manufacturer	MedChem Express
Amount	20 ug
Quantity options	100 ug 10 ug 1 ea 20 ug 2 ug 50 ug 5 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	97.00
Citations	[1]Ono T, et al. RANKL biology: bone metabolism, the immune system, and beyond. Inflamm Regen. 2020 Feb 7;40:2.<br/>[2]Li B, et al. Roles of the RANKL-RANK Axis in Immunity-Implications for Pathogenesis and Treatment of Bone Metastasis. Front Immunol. 2022 Mar 21;13:824117.<br/>[3]Tobeiha M, et al. RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling. Biomed Res Int. 2020 Feb 19;2020:6910312.<br/>[4]Mikami S, et al. Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas. J Pathol. 2009 Aug;218(4):530-9.<br/>[5]Peng X, et al. Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer. PLoS One. 2013;8(3):e58361.<br/>[6]Lloyd SA, et al. Soluble RANKL induces high bone turnover and decreases bone volume, density, and strength in mice. Calcif Tissue Int. 2008 May;82(5):361-72.
Smiles	GSQHIRAEKA MVDGSWLDLA KRSKLEAQPF AHLTINATNI PTGSHKVSLS SWYHDRGWAK ISNMTFSNGK LIVNQDGFYY LYANICFRHH ETSGDLATEY LQLMVYVTKT SIKIPSSHTL MKGGSTKYWS GNSEFHFYSI NVGGFFKLRS GEEISVEVSN PSLLDPDQDA TYFGAFKVRD ID
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	RANKL/TNFSF11 Protein, Cynomolgus (HEK293, Fc),Cynomolgus,HEK293
Available
Product Description	RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human (HEK293, hFc) is a recombinant human RANKL (G63-D244) with N-terminal hFc tag, which is produced in HEK293[1][2].
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
MolecularWeight	Approximately 56 kDa
Manufacturers Product type	Recombinant Proteins

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