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Human FGF R3 (IIIb) / FGF R3B / CD333 Protein, Fc Tag (MALS verified)

Human FGF R3 (IIIb) / FGF R3B / CD333 Protein, Fc Tag (MALS verified)

Manufacturer	ACROBiosystems
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human
Format	Powder
Amount	100 ug
Host	HEK293
Item no.	FGB-H5259-100ug
Conjugate/Tag	Unconjugated, Fc
eClass 6.1	34160400
eClass 9.0	42020190
Available
Alias	FGF R3 (IIIb),FGF R3B,CD333
Purity	95%
Manufacturers Category	Protein / Bio-Markers & CD Antigens
Description	Human FGF R3 (IIIb), Fc Tag (FGB-H5259) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Gly 377 (Accession # P22607-2).
Molecule	FGF R3 (IIIb)
Exp Region	Glu 23 - Gly 377
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	65.0 kDa
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 65.0 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Background	Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc). Upregulated expression of FGFR3 protein is also found in a significant number of tumors. Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCγ signaling cascade.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/26/2024

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