TRANCE/RANK L/TNFSF11

Recombinant Mouse TNF ligand superfamily member 11 is produced by our E.coli expression system and the target gene encoding Gln137-Asp316 is expressed.

Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Greater than 95% as determined by reducing SDS-PAGE.

Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.