Item no. |
CSR-C82H3-1mg |
Manufacturer |
ACROBiosystems
|
Amount |
1 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Dog |
Host |
HEK293 |
Conjugate/Tag |
Unconjugated, HIS |
Purity |
95% |
Citations |
(1) Ridge, et al., 1990, Proceedings of the National Academy of Sciences 87 (4): 1377-80. (2) Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17): 4442-51. (3) Tamimi, R. M., 2008, Cancer Research 68 (1): 18-21. (4) Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20): 9312-6. (5) Sapi, Eva, 2004, Experimental Biology and Medicine 229 (1): 1-11. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR |
Available |
|
Manufacturers Category |
Protein / Bio-Markers & CD Antigens |
Description |
Canine M-CSF R, His Tag (CSR-C82H3) is expressed from human 293 cells (HEK293). It contains AA Val 20 - Pro 510 (Accession # E2RJV2-1). |
Molecule |
M-CSF R |
Exp Region |
Val 20 - Pro 510 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
56.1 kDa |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 56.1 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
PBS, pH7.4 |
Background |
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.