Recombinant Rat Microtubule-associated protein tau(Mapt)

Others

Not Test

Rattus norvegicus (Rat)

AEPRQEFDTMEDQAGDYTMLQDQEGDMDHGLKESP PQPPADDGSEEPGSETSDAKSTPTAEDVTAPLVEE RAPDKQATAQSHTEIPEGTTAEEAGIGDTPNMEDQ AAGHVTQEPQKVEIFSQSLLVEPGRREGQAPDSGI SDWTHQQVPSMSGAPLPPQGLREATHQPLGTRPED VERSHPASELLWQESPQKEAWGKDRLGSEEEVDED ITMDESSQESPPSQASLAPGTATPQARSVSASGVS GETTSIPGFPAEGSIPLPADFFSKVSAETQASPPE GPGTGPSEEGHEAAPEFTFHVEIKASAPKEQDLEG ATVVGAPAEEQKARGPSVGKGTKEASLLEPTDKQP AAGLPGRPVSRVPQLKARVAGVSKDRTGNDEKKAK TSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSP AVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADG KTGAKIATPRGAATPGQKGTSNATRIPAKTTPSPK TPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSL PTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPM PDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLS NVQSKCGSKDNIKHVPGGGSVHIVYKPVDLSKVTS KCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIG SLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGA EIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQL ATLADEVSASLAKQGL

2-752aa

80.4 kDa

Promotes microtubule assbly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma mbrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Greater than 90% as determined by SDS-PAGE.

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited areas of the CNS.