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Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag

Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag

Item no.	CD2-H5257-100ug
Manufacturer	ACROBiosystems
Amount	100 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Powder
Specific against	Human
Host	HEK293
Isotype	IgG2a
Conjugate/Tag	Unconjugated, C-mFc
Purity	95%
Citations	(1) Martinez W.M., et al., 2001, J. Virol. 75:11185-11195. (2) Yu X., et al., 2009, Nat. Immunol. 10:48-57.
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	42020190
ECLASS 9.0	42020190
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD112,Nectin-2,PVRL2
Available
Manufacturers Category	Protein / Immune Checkpoint Proteins
Description	Human Nectin-2, Mouse IgG2a Fc Tag (CD2-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Leu 360 (Accession # Q92692-2).
Molecule	Nectin-2
Exp Region	Gln 32 - Leu 360
Storage	-20℃
Shipping	RT
Stability	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Molecular Weight	62.4 kDa
Characteristics	This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 62.4 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	0.1 EU per μg
Buffer	Tris with Glycine, Arginine and NaCl, pH7.5
Background	Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 8/9/2024

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