Item no. |
BM-RPC26715-100ug |
Manufacturer |
Biomatik
|
Amount |
100ug |
Category |
|
Type |
Proteins Recombinant |
Specific against |
Human |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
TNF ligand-related molecule 1, |
Similar products |
TNF ligand-related molecule 1 |
Available |
|
Gene Name |
TNFSF15, TL1, VEGI |
Alternative Names |
TNF ligand-related molecule 1, |
Uniprot |
O95150 |
Source |
E.coli |
Expression Region |
72-251aa |
AA Sequence |
LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VR QTPTQHFK NQFPALHWEH ELGLAFTKNR MNYT NKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQ AGRP NKPDSITVVI TKVTDSYPEP TQLLMGTK SV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL |
Sequence Info |
Partial |
Tag Info |
Tag-Free |
Theoretical MW |
20.5 kDa |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
Storage Buffer |
Lyophilized from a 0.2 um filtered PBS, pH 7.4, with 0.02% Tween-20 |
Endotoxin Level |
Less than 1.0 EU/ug as determined by LAL method. |
Biological Activity |
The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20 ng/ml, corresponding to a specific activity of ? 5.0 x 104 IU/mg. |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269|PubMed:10597252, ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9872942}. |
Function |
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. |
Subcellular location |
Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted |
Protein Families |
Tumor necrosis factor family |
Tissue Specificity |
Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.