Recombinant Human Filamin-A (FLNA), partial

Actin-binding protein 280 (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) (FLN-A) (FLN) (FLN1)

E.coli

SSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLA EDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDL SDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLEN VSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLI WTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWI QNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCP DWDSWDASKPVTNAREAMQQADDWLGIPQVITPEE IVDPNVDEHSVMTYLSQFPKAKLKPGAP

N-terminal 10xHis-tagged and C-terminal Myc-tagged

>85% as determined by SDS-PAGE.

Not tested

Ice packs

1 year

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance.