Recombinant Human Dynamin-1-like protein (DNM1L)

Dnm1p/Vps1p-like protein (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less ) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) (DLP1) (DRP1)

E.coli

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQS SGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHV SQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFD EIRQEIENETERISGNNKGVSPEPIHLKIFSPNVV NLTLVDLPGMTKVPVGDQPKDIELQIRELILRFIS NPNSIILAVTAANTDMATSEALKISREVDPDGRRT LAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVV NRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRN GTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQY QSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEG TAKYIETSELCGGARICYIFHETFGRTLESVDPLG GLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQ IKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELL RFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIE LAYINTKHPDFADACGLMNNNIEEQRRNRLARELP SAVSRDKLIQDSRRETKNVASGGGGVGDGVQEPTT GNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGH AVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFL IVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLY KSSLLDDLLTESEDMAQRRKEAADMLKALQGASQI IAEIRETHLW

N-terminal 10xHis-tagged and C-terminal Myc-tagged

>85% as determined by SDS-PAGE.

Not tested

Ice packs

1 year

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

Encephalopathy due to defective mitochondrial and peroxisomal fission 1 (EMPF1)

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

TNFsignalingpathway