Item no. |
BM-RPC25634-1mg |
Manufacturer |
Biomatik
|
Amount |
1mg |
Category |
|
Type |
Proteins Recombinant |
Specific against |
Human (Homo sapiens) |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Gene Name |
CALM1 |
Uniprot |
P0DP23 |
Source |
E.coli |
Expression Region |
2-149aa |
AA Sequence |
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTV MRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLT MMARKMKDTDSEEEIREAFRVFDKDGNGYISAAEL RHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEE FVQMMTAK |
Sequence Info |
Full Length of Mature Protein |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
Theoretical MW |
32.7 kDa |
Purity |
>85% as determined by SDS-PAGE. |
Storage Buffer |
Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Endotoxin Level |
Not tested |
Biological Activity |
Not tested |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. |
Function |
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis |
Involvement in disease |
Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4); Long QT syndrome 14 (LQT14) |
Subcellular location |
Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, spindle pole |
Protein Families |
Calmodulin family |
Paythway |
Excitatorysynapsepathway |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.