Item no. |
BM-RPC25613-100ug |
Manufacturer |
Biomatik
|
Amount |
100ug |
Category |
|
Type |
Proteins Recombinant |
Specific against |
Mouse (Murine, Mus musculus) |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
1-O-acylceramide synthase1 Short name: ACS LCAT-like lysophospholipase Short name: LLPL Lysophospholipase 3 Lysosomal phospholipase A22 Short name: LPLA2 |
Similar products |
1-O-acylceramide synthase1 Short name: ACS LCAT-like lysophospholipase Short name: LLPL Lysophospholipase 3 Lysosomal phospholipase A22 Short name: LPLA2 |
Available |
|
Gene Name |
Pla2g15 |
Alternative Names |
1-O-acylceramide synthase1 Short name: ACS LCAT-like lysophospholipase Short name: LLPL Lysophospholipase 3 Lysosomal phospholipase A22 Short name: LPLA2 |
Uniprot |
Q8VEB4 |
Source |
E.coli |
Expression Region |
34-412aa |
AA Sequence |
AQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKK TDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSR ATQFPDGVDVRVPGFGETFSMEFLDPSKRNVGSYF YTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPY FLALREMIEEMYQMYGGPVVLVAHSMGNVYMLYFL QRQPQVWKDKYIHAFVSLGAPWGGVAKTLRVLASG DNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSH EKVFVYTPTTNYTLRDYHRFFRDIGFEDGWFMRQD TEGLVEAMTPPGVELHCLYGTGVPTPNSFYYESFP DRDPKICFGDGDGTVNLESVLQCQAWQSRQEHRVS LQELPGSEHIEMLANATTLAYLKRVLLEP |
Sequence Info |
Full Length of Mature Protein |
Tag Info |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Theoretical MW |
50.5 kDa |
Purity |
>85% as determined by SDS-PAGE. |
Storage Buffer |
Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Endotoxin Level |
Not tested |
Biological Activity |
Not tested |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen |
Function |
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid |
Subcellular location |
Secreted, Lysosome, Membrane, Peripheral membrane protein |
Protein Families |
AB hydrolase superfamily, Lipase family |
Tissue Specificity |
Detected in blood plasma (PubMed:20410020). Detected in alveolar macrophages (at protein level) (PubMed:16106046, PubMed:16880524, PubMed:19017977). Detected in heart, liver, spleen, kidney, thymus, brain and lung (PubMed:16880524). |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.