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Recombinant Human Prolactin receptor (PRLR)

Recombinant Human Prolactin receptor (PRLR)

Item no.	BM-RPC20748-100ug
Manufacturer	Biomatik
Amount	100ug
Category	Oncology By Cell Type Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Gene Name	PRLR
Uniprot	P16471
Source	in vitro E.coli expression system
Expression Region	25-622aa
AA Sequence	QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTN YSLTYHREGETLMHECPDYITGGPNSCHFGKQYTS MWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDP PLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWF TLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPG QKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMND TTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFP PVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPT SDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMK PTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTF YDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAG GSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPA GAPATLLNEAGKDALKSSQTIKSREEGKATQQREV ESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHK VNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKV SGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLE QNQAEKALANFTATSSKCRLQLGGLDYLDPACFTH SFH
Sequence Info	Full Length of Mature Protein
Tag Info	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Theoretical MW	71.9 kDa
Purity	>85% as determined by SDS-PAGE.
Storage Buffer	Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Endotoxin Level	Not tested
Biological Activity	Not tested
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Involvement in disease	Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)
Subcellular location	Membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Secreted
Protein Families	Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas.
Paythway	Jak-STATsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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Delivery expected until 9/27/2024

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