Item no. |
APL-H5267-1mg |
Manufacturer |
ACROBiosystems
|
Amount |
1 mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Conjugate/Tag |
Unconjugated;Fc Tag |
Purity |
>95% as determined by SDS-PAGE. |
Citations |
(1) Garcia-Castro A, et al. 2015, Carcinogenesis., 36(5):574-84. (2) Schuepbach-Mallepell S, et al. 2015, J Biol Chem., 290(26):16330-42. (3) Zhi X, et al. 2015, Cell Physiol Biochem, 35(2):571-85. |
ECLASS 5.1 |
34160400 |
ECLASS 6.1 |
34160400 |
ECLASS 8.0 |
42020190 |
ECLASS 9.0 |
42020190 |
ECLASS 10.0.1 |
32160409 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
APRIL,TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2 |
Available |
|
Buffer |
Tris with Glycine, Arginine and NaCl, pH7.5 |
Characteristics |
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 42.8 kDa. The protein migrates as 48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Description |
APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells. |
Endotoxin Level |
Less than 1.0 EU per ug by the LAL method. |
Exp Region |
Ala 105 - Leu 250 |
Expression System |
HEK293 |
Molecular Weight |
42.8 kDa |
Molecule |
APRIL |
Shipping Conditions |
RT |
Storage |
-20C |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.