Human IL36-gamma protein

The recombinant Human IL36-gamma consists of 152 amino acids and has a predicted molecular mass of 16.7 kDa.

>98% as determined by SDS-PAGE

Endotoxin: <1 EU per ug of the protein as determined by the LAL method.

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL36-gamma protein using the buffer we provided not less than 100 ug/mL, which can then be further diluted to other aqueous solutions.

The product is shipped at ambient temperature.

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 alpha (IL-1F6), beta (IL-1F8) and gamma (IL-1F9). IL-36gamma is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36gamma signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36gamma also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells.

Interleukin 36 GammaInterleukin-1 Homolog 1; Interleukin-1 Epsilon; IL-1RP2; IL-1F9 ; IL-1H1 ; IL1H1; IL1E; Interleukin 1-Related Protein 2 ; Interleukin-36 Gamma; IL1RP2; IL1F9

IL36-gamma