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Cyclosporin-A

Cyclosporin-A

Manufacturer	ProSpec
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	other
Amount	1gram
Item no.	pro-408-1gram
eClass 6.1	34160400
eClass 9.0	42020190
Available
Introduction	Cyclosporin A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless, Cyclosporin A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism.
Description	Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a molecular weight of 1202.64. It is produced as a metabolite by the fungus species Beauveria nlyea. Chemically, cyclosporin is designated as [R-[R, R-(E)]]-cyclic(L-alanyl-D- alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L--amino-butyryl- N-methylglycyl-N- methyl-L-leucyl-L-valyl-N-methyl-L-leucyl). Molecular Formula: C₆₂H₁₁₁N₁₁O₁₂.
Source	Beauveria Nlyea.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	The Cyclosporin-A was lyophilized from a concentrated (1mg/ml) solution with no additives.
Purity	Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage	Lyophilized Cyclosporin A although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Cyclosporin A should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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pro-408-1gram-safety-datasheet.pdf