Recombinant Human Interleukin-5

The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

Escherichia Coli.

Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.

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The ED50 as determined by the dose-dependant stimulation of the proliferation of TF-1 cells was found to be 0.15ng/ml, corresponding to a Specific Activity of 6 x 10⁶ IU/mg.